Dr. Bernard Bihari recommended the nutritional supplement known as DL-Phenylalanine (DLPA) to enhance the effectiveness of LDN. It also acts as a mild antidepressant and pain-killer. The recommended dose is 500 mg in the morning and 500 mg in the afternoon, both on an empty stomach. There are, however, a number of precautions involved in using DLPA. It should not be taken, for example, if you have high blood pressure.
DL-Phenylalanine blocks the enzymes responsible for the breakdown of endorphins and enkephlins. Endorphins and enkephlins are a group of substances within the body that helps relieve pain. Endorphins are actually far more powerful than the drug known as morphine. Small cells throughout the nervous system, brain, spinal cord, and nerve endings are able to produce these morphine-like proteins.
DL-Phenylalanine: The amino acid DL-phenylalanine has been reported to slow down the breakdown of endorphins and other painkillers. Daytime usage of this amino acid (taken on an empty stomach) may help to sustain the benefit of nighttime usage of naltrexone by maintaining high levels of endorphins.
What is DL-Phenylalanine?
DL-Phenylalanine (DLPA) is a mixture of the naturally occurring amino acid L-Phenylalanine and its isomer D-Phenylalanine. In addition to supporting the production of the excitory neurotransmitters epinephrine and norepinephrine, DLPA has been used as a mood elevator/depression, appetite suppression and chronic pain. DLPA also helps relieve discomfort by prolonging the activity of enkephalins, the body’s own pain-blocking neuropeptides. DLPA has been used successfully for the management of chronic pain and may be effective in a number of endorphin deficiency states such as depression and arthritis.
Recommended Dosage: 1 to 4 capsules per day on an empty stomach.
DLPA is not intended for use by phenylketonurics, or during pregnancy. If you have high blood pressure or are prone to anxiety or panic attacks, do not take DLPA without consulting your health care professional.
DLPA, dl- phenylalanine, Arthritis, conventional treatments, alternative remedies, complementary therapies, integrative therapies, mind-body therapies
DL-Phenylalanine has helped many with depression and pain and sustaining endorphin levels throughout the day after LDN the night before.
Also, D-Phenylalanine--4 CHRONIC PAIN CONTROL
What are the benefits of D-Phenylalanine?
• Elevating endorphin levels associated with pain endurance
• Providing relief from arthritis, and other back and joint pains
• Helps feelings of stress and frustration
• Control the cravings for addictive substances
What is D-Phenylalanine? It is the dextrorotatory form of the amino acid Phenylalanine. The L-forms (levorotatory) of amino acids are ones that are bioavailable and are for protein synthesis and regulatory function. The L and D forms are like mirror images of one another, however the D-Phenylalanine is not absorbed into the body, but acts as an inhibiting agent to the enzymes that are responsible for the breakdown of endorphins, which control pain perception.
D-Phenylalanine and Endorphins; Endorphins are naturally occurring opiate-like peptides, which control pain perception and produce an analgesic effect. Their effects are only of short duration because of metabolic enzymes, especially Carboxypeptidase A. D-Phenylalanine prohibits these enzymes, allowing increased endorphin production, therefore prolonging and intensifying analgesic effects.
How does D-Phenylalanine effect pain? Low levels of endorphins have been noted on those suffering from chronic pain, and supplementation with D-Phenylalanine helped to increase these levels. By prohibiting carboxypeptidase A from preventing endorphin production, the body can continue to increase its own natural tolerance mechanism. In studies with chronic pain patients, the pain threshold has been enhanced and prolonged. This has been effective with various chronic pain conditions, including back pain and osteoarthritis.
How can D-Phenylalanine help cravings? When the body lacks endorphins, cravings may arise for foods or drugs that temporarily elevate endorphins. Once these spikes of endorphins begin to wear off, withdrawal symptoms may occur. Supplementation with D-Phenylalanine helps to keep these levels up. Therefore D-Phenylalanine may help to control these cravings.
D-Phenylalanine and Acupuncture Pre-administration or D-Phenylalanine enhances the effects of acupuncture on back and other pain. Up to 2 grams one hour prior to acupuncture treatment may result in more pain relief and for longer periods of time.
Dental Pain Two grams of D-Phenylalanine has been given one hour prior to dental extractions, thus increasing the pain threshold for a prolonged period of time.
Why NOT DLPA (a combination of both D-Phenylalanine and L-Phenylalanine and L-Phenylalanine) ? D-Phenylalanine is the form of phenylalanine that effects endorphins production. L-Phenylalanine has other functions in the body. D-Phenylalanine will assist in pain tolerance to those needing this function. By combining the two, the concentration of the effective form of D-Phenylalanine would be less effective, therefore more would be required to achieve results. The Third World Congress on Pain recommended D-Phenylalanine and numerous medical studies have confirmed this recommendation. Some suggest that L-Phenylalanine will stimulate catecholamine production for those whose pain causes depression. Since L-Phenylalanine must convert to L-Tyrosine in the body in order to raise neurotransmitter levels, it would be best to take L-Tyrosine alone for this purpose. In some forms of depression patients have responded to D-Phenylalanine. In addition, L-Phenylalanine is not recommended for those with elevated blood pressure levels, diabetes, or pregnant women, therefore would not be the best choice for mood enhancement or pain relief. D-Phenylalanine is the recommended form of Phenylalanine for chronic pain control.
CAUTION: This product NOT intended for use by people with PKU(Phenylketonuria), or pregnant or lactating women. If you have high blood pressure or pre-existing pigmented malignant melanoma, use only under the guidance of a physician. Do NOT take with MAO inhibitor antidepressant drugs. Caution:Cancer patients should avoid taking L-phenylalanine and L-Tyrosine. Certain cancers, such as melanoma, depend on these amino acids to fuel their growth. Supplemental use of L-phenylalanine and L-Tyrosine may raise or normalize blood